Biomarkers in predicting myocardial damage in athletes

Abstract

The dynamics of autoantibodies (AAB) to cardiomyocyte proteins in the blood of basketball athletes in the dynamics of a one-year training cycle was shown. Men aged 19-23 years old with different amounts of total motor activity were examined. Anthropo-and physiometric examinations, electrocardiogram measurements, general blood analysis, quantitative determination of AAB to cardiomyocyte proteins, and the concentration of sex hormones were carried out. In individuals with high total motor activity, the amount of AAB to myocardial proteins (alpha-actin 1, beta-myosin 7B, and troponin I) was higher compared to peers who did not engage in sports. At the end of the competition period, two players had a more than 5-fold excess of AAB to troponin I compared to the average values determined in the group of other team members. At the same time, there were minor changes in electrocardiogram and the absence of complaints about the condition of the cardiovascular system. A multiple increase in the content of AAB to myocardial proteins during the period of intensification of training loads is recorded in the absence of obvious signs of pathological changes in the heart and complaints from the subject. This indicates the prospects of determining AAB to cardiomyocyte proteins and, first of all, AAB to troponin I as an indicator of early signs of incipient pathological changes in the myocardium.