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Title: Cyclopropene-templated assembly of medium cycles via ru-catalyzed ring-closing metathesis
Authors: Rubin, M. A.
Рубин, М. А.
Keywords: Cycloaddition Reaction;Cyclopropenes;Vinylcarbene
Issue Date: 2020
Publisher: American Chemical Society
Citation: Yamanushkin, P., Smith, S.P., Petillo, P.A., Rubin, M. Cyclopropene-Templated Assembly of Medium Cycles via Ru-Catalyzed Ring-Closing Metathesis // Organic Letters. - 2020. - Volume 22. - Issue 9. - Pages 3542-3546
Series/Report no.: Organic Letters
Abstract: An expeditious click-click cyclize strategy for the assembly of medium-sized heterocyclic rings is described. The sequence involves the reaction of cycloprop-2-ene carboxylic acids with unsaturated amines to furnish amides, which are further subjected to a Cu-catalyzed directed carbomagnesiation and a ring-closing olefin metathesis reaction. This methodology allows for the efficient preparation of lactams with ring sizes up to 10
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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