Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/13876
Title: Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity
Authors: Aksenov, N. A.
Аксенов, Н. А.
Aksenov, A. V.
Аксенов, А. В.
Kirilov, N. K.
Кирилов, Н. К.
Arutiunov, N. A.
Арутюнов, Н. А.
Aksenov, D. A.
Аксенов, Д. А.
Rubin, M. A.
Рубин, М. А.
Keywords: Neuroblastoma;Nitroalkanes;Synthesis of triazole-fused heterocycles;Neuroblastoma therapy
Issue Date: 2020
Publisher: NLM (Medline)
Citation: Aksenov, N.A., Aksenov, A.V., Kirilov, N.K., Arutiunov, N.A., Aksenov, D.A., Maslivetc, V., Zhao, Z., Du, L., Rubin, M., Kornienko, A. Nitroalkanes as electrophiles: synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity // Organic & biomolecular chemistry. - 2020. - Volume 18. - Issue 34. - Pages 6651-6664
Series/Report no.: Organic and Biomolecular Chemistry
Abstract: We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4',3'-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma
URI: http://hdl.handle.net/20.500.12258/13876
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