Matrix metalloproteinases and their tissue inhibitors in the pathogenesis of periodontal diseases in type 1 diabetes mellitus

Abstract

The item presents the results of a comparative immune enzymometric assay of the matrix metalloproteinases (MMP-1, MMP-2, MMP-8, MMP-9) and tissue inhibitors (TIMP-1, TIMP-2) levels in blood serum, oral fluid of children belonging to Health Groups I and II and children with type 1 diabetes mellitus (disease course within the range of 1 to 10 years) in projection onto the level of hygiene and the periodontal status. The role of MMP-2, MMP-8, MMP-9 in the pathogenetic mechanisms of inflammatory periodontal diseases development has been identified. Children with a short experience of endocrinopathy were found to have a balanced synthesis of matrix metalloproteinases and their tissue inhibitors in case of reversible inflammatory alterations in periodontal tissues. Children with a longer disease course were found to feature an imbalance between matrix metalloproteinases and tissue inhibitors, which provokes disturbances in remodeling and structural organization of the extracellular matrix in periodontal tissues, along with the development of inflammatory destructive issues