Influence of prenatal hypoglycemia on the adaptive possbilities of the hypothalamo-hypophyseal-Adrenocortical system and resistance to stress in rats

Abstract

We studied the blood glucose content, functional state of HHACS and its response to stressors in female rats exposed to insulin hypoglycemia during pregnancy, as well as in their offspring. It was found that hypoglycemia during pregnancy causes stressful activation of HHACS in comparison the level of physiological pregnancy. Episodic hypoglycemia of the mother leads to a two-phase reaction of HHACS of her offspring: An increase in functional activity in the late prenatal and early postnatal periods (-1-30 days) and a subsequent decrease (45-365 days) compared with the control group. Both phases are characterized by a decrease in resistance to extreme muscular loads, immobilization, as well as depletion of HHACS, which is most pronounced during neonatal period, puberty and 12 months of age