Please use this identifier to cite or link to this item:
https://dspace.ncfu.ru/handle/20.500.12258/18106
Title: | In-vitro study of the properties of components for the synthesis of sorbent for low-density lipoprotein apheresis |
Authors: | Povetkin, S. N. Поветкин, С. Н. |
Keywords: | Sorbent;Apolipoprotein;Aerosil;Low-density lipoproteins |
Issue Date: | 2021 |
Publisher: | JADOUN SCIENCE PUBLISHING GROUP |
Citation: | Bazhenova, A. A.; Guryanova, N. I.; Guryanov, G. S.; Alieva, H. A. V.; Kachmazova, D. T.; Khripunova, A. A.; Povetkin, S. N. In-vitro study of the properties of components for the synthesis of sorbent for low-density lipoprotein apheresis // PHARMACOPHORE. - 2021. - Том 12. - Выпуск 3. - Стр.: 37-41 |
Series/Report no.: | PHARMACOPHORE |
Abstract: | The research was carried out based on the Stavropol State Medical University. This work aimed to study the fundamental possibility of creating an immunosorbent for LDL apheresis based on non-porous highly dispersed silicon dioxide and monospecific polyclonal antibodies. In the course of the study, a matrix was selected for the synthesis of an immunosorbent based on aerosil modified with dextran. Affinity-purified rabbit polyclonal antibodies to human apolipoprotein B (ApoB) were immobilized onto the matrix. The obtained sample of the immunosorbent under in-vitro conditions showed good sorption properties to LDL, which makes it promising for further work on the creation of a sorbent for LDL-apheresis. It is concluded that the fundamental possibility of creating an immunosorbent based on non-porous highly dispersed silicon dioxide and monospecific polyclonal antibodies has been shown, which makes it possible to effectively bind and remove LDL from the blood plasma |
URI: | http://hdl.handle.net/20.500.12258/18106 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Size | Format | |
---|---|---|---|
WoS 1179 .pdf Restricted Access | 330.88 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.