Synthesis and some properties of new 5-Hydroxy-2-[(hetarylthio)methyl]-4H-pyran-4-ones

Abstract

The reaction of 2-thioxoazines with chlorokojic acid in the presence of KOH in DMF led to the formation of new hybrid molecules containing fragments of kojic acid and azaheterocycle linked by the SCH2 spacer. In silico prediction of bioavailability parameters was carried out, possible protein targets were predicted by the protein ligand docking method.