Please use this identifier to cite or link to this item:
https://dspace.ncfu.ru/handle/20.500.12258/18555
Title: | An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes |
Authors: | Abaev, V. T. Абаев, В. Т. |
Keywords: | Indole;Reduction;Catalytic olefination reaction;CF3-group;Fluorine;Nitro group |
Issue Date: | 2021 |
Publisher: | MDPI |
Citation: | Muzalevskiy, V. M., Sizova, Z. A., Abaev, V. T., Nenajdenko, V. G. An efficient approach to 2-CF3-indoles based on ortho-nitrobenzaldehydes // Molecules. - 2021. - Том 26. - Выпуск 23. - Номер статьи 7365. - DOI10.3390/molecules26237365 |
Series/Report no.: | Molecules |
Abstract: | The catalytic olefination reaction of 2-nitrobenzaldehydes with CF3 CCl3 afforded stereose-lectively trifluoromethylated ortho-nitrostyrenes in up to 88% yield. The reaction of these alkenes with pyrrolidine permits preparation of α-CF3-β-(2-nitroaryl) enamines. Subsequent one pot reduction of nitro-group by Fe-AcOH-H2 O system initiated intramolecular cyclization to afford 2-CF3-indoles. Target products can be prepared in up to 85% yields. Broad synthetic scope of the reaction was shown as well as some followed up transformations of 2-CF3-indole. |
URI: | http://hdl.handle.net/20.500.12258/18555 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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scopusresults 1990 .pdf Restricted Access | 4.41 MB | Adobe PDF | View/Open | |
WoS 1341 .pdf Restricted Access | 83.96 kB | Adobe PDF | View/Open |
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