Effect of hyperestrogenemia on the development of cervical intraepithelial neoplasia in the case of human papillomavirus

Abstract

The article describes the study of the hormonal status of the human papillomavirus (HPV) carrying patients with the developed low-severity squamous intraepithelial lesion (LSIL). The aim of the study was to identify the relationship between elevated serum estradiol levels and the development of mild cervical intraepithelial neoplasia (CIN I). The number of analyzed samples included in the control and experimental groups was determined. Cytological preparations of cervical scraping were prepared and stained by the automated BD PrepStain system. The genotyping of HPV was carried out by sampling the material of the cervical canal. The hormonal status of patients in three age groups was analyzed. The results of the cytological examination, PCR, and hormonal analysis of the groups were compared with each other. In most patients of the experimental group, an increase in serum estradiol, prolactin, cortisol, and FSH was noted. It was also revealed that the majority of patients with elevated levels of serum estradiol had cervical intraepithelial neoplasia (CIN I). It was experimentally established that the percentage of dysplasia development with elevated estradiol levels has similar values in the case of HPV-16, HPV-18, and other genotypes.