Please use this identifier to cite or link to this item:
https://dspace.ncfu.ru/handle/20.500.12258/18694
Title: | Phytochemical characterization, antioxidant activity, and cytotoxicity of methanolic leaf extract of Chlorophytum comosum (Green Type) (Thunb.) Jacq |
Authors: | Rzhepakovsky, I. V. Ржепаковский, И. В. Avanesyan, S. S. Аванесян, С. С. Kurchenko, V. P. Курченко, В. П. Sizonenko, M. N. Сизоненко, М. Н. Timchenko, L. D. Тимченко, Л. Д. |
Keywords: | Antioxidant activity;Cytotoxicity;Biological active substances;Herbal medicine;Chlorophytum comosum |
Issue Date: | 2022 |
Publisher: | MDPI |
Citation: | Rzhepakovsky, I. V., Areshidze, D. A., Avanesyan, S. S., Grimm W. D., Filatova N. V., Kalinin A. V., Kochergin S. G., Kozlova M. A., Kurchenko V. P., Sizonenko M. N., Terentiev A. A., Timchenko, L. D. Phytochemical characterization, antioxidant activity, and cytotoxicity of methanolic leaf extract of Chlorophytum comosum (Green Type) (Thunb.) Jacq // Molecules. - 2022. - Том 27. - Выпуск 3. - Номер статьи 762. - DOI10.3390/molecules27030762 |
Series/Report no.: | Molecules |
Abstract: | Chlorophytum genus has been extensively studied due to its diverse biological activities. We evaluated the methanolic extract of leaves of Chlorophytum comosum (Green type) (Thunb.) Jacques, the species that is less studied compared to C. borivilianum. The aim was to identify phytoconstituents of the methanolic extract of leaves of C. comosum and biological properties of its different fractions. Water fraction was analyzed with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. Nineteen compounds belonging to different chemical classes were identified in the methanolic extract of leaves of C. comosum (Green type) (Thunb.) Jacques. In addition to several fatty acids, isoprenoid and steroid compounds were found among the most abundant constituents. One of the identified compounds, 4′-methylphenyl-1C-sulfonyl-β-D-galactoside, was not detected earlier in Chlorophytum extracts. The water fraction was toxic to HeLa cells but not to Vero cells. Our data demonstrate that methanolic extract of leaves of C. comosum can be a valuable source of bioactive constituents. The water fraction of the extract exhibited promising antitumor potential based on a high ratio of HeLa vs. Vero cytotoxicity. |
URI: | http://hdl.handle.net/20.500.12258/18694 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
scopusresults 2043 .pdf Restricted Access | 8.83 MB | Adobe PDF | View/Open | |
WoS 1371 .pdf Restricted Access | 85.05 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.