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Title: | 7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity |
Authors: | Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
Keywords: | Aminomethylation;[1,2,4]triazolo[1,5-a]pyridines;Cyanoacetohydrazide;Malononitrile;Oxymethylation;The Mannich reaction |
Issue Date: | 2022 |
Publisher: | Pleiades journals |
Citation: | Dolganov, A. A., Levchenko, A. G., Dahno, P. G., Guz’ D. D., Chikava A. R., Dotsenko, V. V., Aksenov, N. A., Aksenova, I. V. 7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity // Russian Journal of General Chemistry. - 2022. - Том 92. - Выпуск 2. - Стр.: 185 - 197. - DOI10.1134/S1070363222020074 |
Series/Report no.: | Russian Journal of General Chemistry |
Abstract: | Aminomethylation of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles under the action of excess of formaldehyde in ethanol has led to the formation of 7-aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles. Bioavailability parameters of the obtained compounds have been predicted in silico and the possible protein targets have been predicted via the protein-ligand docking. |
URI: | http://hdl.handle.net/20.500.12258/19325 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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scopusresults 2108 .pdf Restricted Access | 1.14 MB | Adobe PDF | View/Open | |
WoS 1391 .pdf Restricted Access | 169.54 kB | Adobe PDF | View/Open |
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