Please use this identifier to cite or link to this item: https://dspace.ncfu.ru/handle/20.500.12258/19325
Title: 7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity
Authors: Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Keywords: Aminomethylation;[1,2,4]triazolo[1,5-a]pyridines;Cyanoacetohydrazide;Malononitrile;Oxymethylation;The Mannich reaction
Issue Date: 2022
Publisher: Pleiades journals
Citation: Dolganov, A. A., Levchenko, A. G., Dahno, P. G., Guz’ D. D., Chikava A. R., Dotsenko, V. V., Aksenov, N. A., Aksenova, I. V. 7-Aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles: Synthesis and Predicted Biological Activity // Russian Journal of General Chemistry. - 2022. - Том 92. - Выпуск 2. - Стр.: 185 - 197. - DOI10.1134/S1070363222020074
Series/Report no.: Russian Journal of General Chemistry
Abstract: Aminomethylation of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles under the action of excess of formaldehyde in ethanol has led to the formation of 7-aryl-3-(hydroxymethyl)-5-oxo-1,2,3,5-tetrahydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitriles. Bioavailability parameters of the obtained compounds have been predicted in silico and the possible protein targets have been predicted via the protein-ligand docking.
URI: http://hdl.handle.net/20.500.12258/19325
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

Files in This Item:
File Description SizeFormat 
scopusresults 2108 .pdf
  Restricted Access
1.14 MBAdobe PDFView/Open
WoS 1391 .pdf
  Restricted Access
169.54 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.