Investigation of the acute, subacute and chronic toxicity of curcuminoids with native and hydroxypropylated β-cyclodextrin complex nanostructures

Abstract

Toxicological and hygienic assessment of the obtained samples of curcuminoid nanostructures with cyclodestrins showed differences in hazard classes, when studied in the T. pyriformis model system under the conditions of an acute and subacute experiment. In a model system with protozoa, the resulting nanocomplexes were assigned to hazard classes 4 and 2. The study on outbred Wistar rats showed no toxic effect of curcuminoid nanocomplex preparations on the body of experimental animals under conditions of a chronic experiment. Based on the results of assessing the biochemical and hematological parameters of the blood in the control and experimental groups, a significant positive effect of oral administration of curcuminoid nanostructures with native and hydroxypropylated β-cyclodextrin on rats was shown. The administration of drugs for 20 days showed the objective increase in the antioxidant status of the body, increased immunity and to the significant analgesic effect on rats.