Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines

Please use this identifier to cite or link to this item: https://dspace.ncfu.ru/handle/20.500.12258/19633

Title:	Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines
Authors:	Shcherbakov, S. V. Щербаков, С. В. Magometov, A. Y. Магометов, А. Ю. Vendin, M. V. Вендин, М. В. Shcherbakova, V. Y. Щербакова, В. Ю. Aksenov, N. A. Аксенов, Н. А. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А.
Keywords:	Acetylenes;Cationic rearrangements;Heterocyclic chemistry;Reaction mechanisms;Synthetic methodology
Issue Date:	2022
Publisher:	Elsevier Ltd
Citation:	Shcherbakov, S. V., Magometov, A. Y., Vendin, M. V., Shcherbakova, V. Y., Aksenov, N. A., Aksenov, A. V., Naji, O., Rubin, M. Investigation of cationic transformations involving 5-ethynyl-4-arylpyrimidines // Tetrahedron. - 2022. - Номер статьи 132796. - DOI10.1016/j.tet.2022.132796
Series/Report no.:	Tetrahedron
Abstract:	An innovative synthetic approach towards 5-ethynyl-4-arylpyrimidines was developed involving acid-catalyzed electrophilic alkylation of phenols with 5-bromopyrimidine, followed by oxidation and palladium-catalyzed Sonogashira cross-coupling reaction. Reactions of these compounds in the presence of trifluoromethanesulfonic acid were investigated. It was discovered these reactions take a different route for precursors with a different position of phenol group in an arene substituent.
URI:	http://hdl.handle.net/20.500.12258/19633
Appears in Collections:	Статьи, проиндексированные в SCOPUS, WOS

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