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Please use this identifier to cite or link to this item: https://dspace.ncfu.ru/handle/20.500.12258/21197
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dc.contributor.authorDotsenko, V. V.-
dc.contributor.authorДоценко, В. В.-
dc.contributor.authorAksenov, N. A.-
dc.contributor.authorАксенов, Н. А.-
dc.contributor.authorAksenova, I. V.-
dc.contributor.authorАксенова, И. В.-
dc.date.accessioned2022-09-15T08:38:58Z-
dc.date.available2022-09-15T08:38:58Z-
dc.date.issued2022-
dc.identifier.citationKrivokolysko, D. S., Dotsenko, V. V., Bibik, E. Y., Samokish, A. A., Venidiktova, Y. S., Frolov, K. A., Krivokolysko, S. G., Pankov, A. A., Aksenov, N. A., Aksenova, I. V. New Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studies. - Russian Journal of Bioorganic Chemistry. - 2022. - Том 48. - Выпуск 3. - Страницы 628 - 635. - DOI10.1134/S1068162022030104ru
dc.identifier.urihttp://hdl.handle.net/20.500.12258/21197-
dc.description.abstractNew hybrid molecules bearing furyl and 1,4-dihydronicotinonitrile (or 1,4,5,6-tetrahydronicotinonitrile) fragments have been prepared. The analgesic activity was studied in vivo (rats) in acetic acid-induced writhing test. Some compounds showed activity exceeding that of the reference compound (metamizole). Molecular docking was performed with all the compounds against COX-1 and COX-2. Also, we performed the docking studies in order to find new possible protein targets.ru
dc.language.isoenru
dc.publisherPleiades journalsru
dc.relation.ispartofseriesRussian Journal of Bioorganic Chemistry-
dc.subject1,4,5,6-tetrahydropyridinesru
dc.subject1,4-dihydropyridinesru
dc.subjectAnalgesicsru
dc.subjectMolecular dockingru
dc.subjectNicotinonitrilesru
dc.titleNew Hybrid Molecules Based on Sulfur-Containing Nicotinonitriles: Synthesis, Analgesic Activity in Acetic Acid-Induced Writhing Test, and Molecular Docking Studiesru
dc.typeСтатьяru
vkr.instХимико-фармацевтический факультетru
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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