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Title: The Reactions of N,N′-Diphenyldithiomalondiamide with Arylmethylidene Meldrum’s Acids
Authors: Dotsenko, V. V.
Доценко, В. В.
Aksenov, A. V.
Аксенов, А. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Keywords: Active methylene compounds;Meldrum’s acid;Heterocyclization;Dithiomalonamides;Michael adducts
Issue Date: 2022
Citation: Dotsenko, V.V., Aksenov, A.V., Sinotsko, A.E., Varzieva, E.A., Russkikh, A.A., Levchenko, A.G., Aksenov, N.A., Aksenova, I.V. The Reactions of N,N′-Diphenyldithiomalondiamide with Arylmethylidene Meldrum’s Acids // International journal of molecular sciences. - 2022. - 23 (24), статья № 15997. - DOI: 10.3390/ijms232415997
Series/Report no.: International Journal of Molecular Sciences
Abstract: The Michael addition reaction between dithiomalondianilide (N,N′-diphenyldithiomalondi amide) and arylmethylidene Meldrum’s acids, accompanied by subsequent heterocyclization, was investigated along with factors affecting the mixture composition of the obtained products. The plausible mechanism includes the formation of stable Michael adducts which, under the studied conditions, undergo further transformations to yield corresponding N-methylmorpholinium 4-aryl-6-oxo-3-(N-phenylthio-carbamoyl)-1,4,5,6-etrahydropyridin-2-thiolates and their oxidation derivatives, 4,5-dihydro-3H-[1,2]dithiolo[3,4-b]pyridin-6(7H)-ones. The structure of one such product, N-methylmorpholinium 2,2-dimethyl-5-(1-(2-nitrophenyl)-3-(phenylamino)-2-(N-phenylthiocarbamoyl)-3-thioxopropyl)-4-oxo-4H-1,3-dioxin-6-olate, was confirmed via X-ray crystallography.
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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