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Title: | Synthesis and Some Properties of 2-Amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles |
Authors: | Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
Keywords: | 4-hexylresorcinol;Malononitrile;2-amino-4H-chromene-3-carbonitriles;2-amino-4H-pyrans;Calculated biological activity |
Issue Date: | 2022 |
Citation: | Dotsenko, V.V., Khalatyan, K.V., Russkikh, A. A., Varzieva, E.A., Kramareva, D. A., Vasilin, V.K., Aksenov, N. A., Aksenova I.V. Synthesis and Some Properties of 2-Amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene-3-carbonitriles // Russian Journal of General Chemistry. - 2022. - 92(12), pp. 2850-2860. - DOI: 10.1134/S1070363222120374 |
Series/Report no.: | Russian Journal of General Chemistry |
Abstract: | Three-component condensation of aromatic aldehydes with malononitrile and 4-hexylresorcinol in toluene in the presence of a base leads to the formation of 2-amino-4-aryl-6-hexyl-7-hydroxy-4H-chromene- 3-carbonitriles in good yields (79–90%). Structure of the compounds was studied using two-dimensional NMR spectroscopy methods. Bioavailability parameters were predicted in silico, and possible protein targets were predicted by protein-ligand docking. |
URI: | http://hdl.handle.net/20.500.12258/22946 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
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scopusresults 2499 .pdf Restricted Access | 846.52 kB | Adobe PDF | View/Open | |
WoS 1542 .pdf Restricted Access | 114.15 kB | Adobe PDF | View/Open |
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