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Title: A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams
Authors: Aksenov, A. V.
Аксенов, А. В.
Aksenov, D. A.
Аксенов, Д. А.
Kurenkov, I. A.
Куренков, И. А.
Leontiev, A. V.
Леонтьев, А. В.
Aksenov, N. A.
Аксенов, Н. А.
Keywords: 5-hydroxy-3-pyrrolin-2-ones;Cascade transformations;Chalcones;Aldehydes
Issue Date: 2023
Citation: Aksenov, A.V., Aksenov, D.A., Kurenkov, I.A., Leontiev, A.V., Aksenov, N.A. A New, Convenient Way to Fully Substituted α,β-Unsaturated γ-Hydroxy Butyrolactams // International Journal of Molecular Sciences. - 2023. - 24 (12), статья № 10213. - DOI: 10.3390/ijms241210213
Series/Report no.: International Journal of Molecular Sciences
Abstract: The synthesis of novel, highly functionalized 5-hydroxy 3-pyrrolin-2-ones via a two-step procedure involving an addition reaction between KCN and corresponding chalcones, followed by ring condensation of the obtained β-cyano ketones with het(aryl)aldehydes under basic conditions is described. This protocol enables the preparation of various 3,5-di-aryl/heteroaryl-4-benzyl substituted α,β-unsaturated γ-hydroxy butyrolactams, which are subjects of significant interest to synthetic organic and medicinal chemistry.
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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