Please use this identifier to cite or link to this item: https://dspace.ncfu.ru/handle/20.500.12258/26582
Title: Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides
Authors: Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Keywords: 2-thioxo-1,2-dihydropyridine-3-carbonitriles;Antiretroviral therapy;Bis(pyrid-2-yl) disulfides;Cyanothioacetamide;Molecular docking;Oxidation of thioamides
Issue Date: 2023
Citation: Dakhno, P.G., Kindop, V.K., Gordeev, K.V., Zimmer, I.A., Dotsenko, V.V., Temerdashev, A.Z., Vasilin, V.K., Aksenov, N.A., Aksenova, I.V. Oxidation of 4,6-Dimethyl-2-thioxo-1,2-dihydropyridine-3-carbonitriles with Potassium Ferricyanide: Synthesis and Molecular Docking of Bis(pyrid-2-yl) Disulfides // Russian Journal of General Chemistry. - 2023. - 93 (12). - pp. 3043-3054. - DOI: 10.1134/S1070363223120034
Series/Report no.: Russian Journal of General Chemistry
Abstract: The reaction of 4,6-dimethyl-2-thioxo-1,2-dihydropyridin-3-carbonitriles with K3[Fe(CN)6] in an alkaline medium results in the formation of a mixture of oxidation products: bis(3-cyanopyridin-2-yl) disulfides and potassium 3-cyano-4,6-dimethylpyridine-2-sulfonates. Structure of the compounds was confirmed by NMR, IR spectroscopy and high-resolution mass spectrometry. According to the results of molecular docking studies, 2,2′-dithiobis(5-butyl-4,6-dimethylnicotinonitrile) exhibits affinity to the zinc finger domain of the HIV-1 p7 nucleocapsid protein binding.
URI: http://hdl.handle.net/20.500.12258/26582
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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