Analgesic activity of new derivatives of quinazolinone-4

Abstract

In the of study was investigated the antinociceptive action of derivatives of quinazolinone-4 in 187 male and 196 female rats, including females rats in the different stages of the estrous cycle: diestrus 1/2 and proestrus /estrus in models of nociceptive responses induced by chemical stimuli (formalin test, « acetic cramps» ), to assess the level of organization of the peripheral pain sensation. Substances (laboratory code numbers: PGFA - I, II, III, IV, V, VI, VII) at a dose of 2/10 of the molecular weight in mg/kg, reference drugs: metamizole sodium and lidocaine was administered once intraperitoneally 40 minutes before administration of chemical irritants. Control and males received respectively solubilizate Tween-80 and saline (0.4 ml intraperitoneally) under similar conditions. The 4-quinazolinone derivatives compounds I-IV, VI, VII were investigated as potential analgesics. Substance I-IV, VI, VII exhibited analgesic activity in male and female rats. Substances I, VI, VII have analgesic effects on female rats in phase of the estrous cycle diestrus 54; substance I-IV, VI - in the stage of proestrus/estrus. Among the investigated derivatives of quinazolinone-4 compound VI is a leader in analgesic activity