Combined influence of hypo and hypermicroelementosis on functioning of cardiovascular and endocrine systems and anxiety level of adolescents

Abstract

Purpose of investigation: to reveal the combined influence of hypo (Zn, Fe) and hyper (Cd, Pb) microelementosis on functional status of the cardiovascular, endocrine systems and anxiety level of adolescents (13 years of age) living in a chemically contaminated area in Stavropol region. The level of microelements (Cd, Pb, Fe, Zn, Cu) in hair and nails was determined by atomic absorption spectrophotometry method, cortisol in saliva - by ELISA method. The state of the cardiovascular system and its regulatory mechanisms was determined by indicators of variational pulsometry. To assess anxiety level of adolescents test method "Anxiety scale" was used. The analysis of microelement composition of hair and nails in adolescents, living in conditions of chemical environmental pollution with Cd and Pb subliminal doses, revealed the presence of hypo- (Zn, Fe) and hyper- (Cd, Pb) microelementosis. At the same time, increased levels of cortisol in saliva more evident in boys, increased heart rate and mode amplitude, peassure of the central mechanisms of the heart function regulation have been discovered. Change of anxiety level was stated. It has been proved that the determination of the microelement composition of hair and nails can serve as a marker of environmental contamination and complex negative changes, including the imbalance of microelements in hair and nails, functional changes in leading adaptive systems - the hypothalamic-pituitaryadrenocortical axis, cardio-vascular, changes of anxiety level can be used as a marker of dysaptation and predictor of psychosomatic problems