Please use this identifier to cite or link to this item:
|Title:||5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells|
|Authors:||Aksenov, A. V.|
Аксенов, А. В.
|Keywords:||Apoptosis resistance;Glioblastoma;Multidrug resistance;Translation inhibition|
|Publisher:||Elsevier Masson SAS|
|Citation:||Henry, S., Kidner, R., Reisenauer, M.R., Magedov, I.V., Kiss, R., Mathieu, V., Lefranc, F., Dasari, R., Evidente, A., Yu, X., Ma, X., Pertsemlidis, A., Cencic, R., Pelletier, J., Cavazos, D.A., Brenner, A.J., Aksenov, A.V., Rogelj, S., Kornienko, A., Frolova, L.V. 5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells // European Journal of Medicinal Chemistry. - 2016. - Volume 120. - Pages 313-328|
|Series/Report no.:||European Journal of Medicinal Chemistry|
|Abstract:||Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridine ring system were recently shown to be effective at inhibiting proliferation of cancer cells resistant to various pro-apoptotic stimuli and representing tumors with dismal prognoses refractory to current chemotherapy, such as glioma, melanoma, non-small-cell lung, esophageal, head and neck cancers, among others. Using this discovery as a starting point and taking advantage of a concise biomimetic route to the crinine skeleton, a collection of crinine analogues were synthetically prepared and evaluated against cancer cells. The compounds exhibited single-digit micromolar activities and retained this activity in a variety of drug-resistant cancer cell cultures. This investigation resulted in the discovery of new bicyclic ring systems with significant potential in the development of effective clinical cancer drugs capable of overcoming cancer chemotherapy resistance|
|Appears in Collections:||Статьи, проиндексированные в SCOPUS, WOS|
Files in This Item:
|scopusresults 421 .pdf||63.86 kB||Adobe PDF|
|WoS 255 .pdf||108.35 kB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.