Mast cells of thymus, adrenal glands and liver at the acute experimental inflammation and its correction by preparation NICA-EM

Abstract

The conducted research is devoted to investigation of a condition of mast cells system of thymus, liver and adrenal glands of mammals at an acute experimental inflammation under the influence of an immuno-modulatory preparation "NICA-EM". It is shown that at the studied model of an inflammation in control group there is a decrease in number of MCs in a thymus and increase in a liver and adrenal glands. Thus the number of the degranulated MCs increases in all studied organs. Preparation "NICA-EM" renders an anti-inflammatory effect, and system of mast cells of an organism of rats treated with the preparation reacts in the universal way. Thus, action of a preparation brings to uncertainly significant decrease in number of MCs in a thymus and liver in comparison with parameters of intact animals, against increase in their number in adrenal glands. The num-ber of the degranulated MCs in comparison with intact animals increases in thymus and adrenal glands, but thus their number is less, than in control. Thus, the conducted research testifies that application of a prepara-tion "NICA-EM" leads to intensification of degranulation of MCs in the studied organs at acute inflammatory reaction against less considerable, than in control, migration of MCs from a thymus