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dc.contributor.authorAksenov, N. A.-
dc.contributor.authorАксенов, Н. А.-
dc.contributor.authorAksenov, A. V.-
dc.contributor.authorАксенов, А. В.-
dc.contributor.authorAksenov, D. A.-
dc.contributor.authorАксенов, Д. А.-
dc.contributor.authorOvcharov, S. N.-
dc.contributor.authorОвчаров, С. Н.-
dc.contributor.authorRubin, M. A.-
dc.contributor.authorРубин, М. А.-
dc.identifier.citationAksenov, N.A., Aksenov, A., Kornienko, A., De Carvalho, A., Mathieu, V., Aksenov, D.A., Ovcharov, S.N., Griaznov, G.D., Rubin, M. A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities // RSC Advances. - 2018. - Volume 8. - Issue 64. - Pages 36980-36986ru
dc.description.abstractA second generation polyphosphoric acid-mediated one-pot three-component synthesis of indoloquinoline scaffold is developed. This improved version of the process involves electrophilically activated nitroalkanes for the installation of strategic C-C and C-N bonds and ring C assembly. This modification allows the elimination of unnecessary solvent change operations and all steps are carried out in a true, uninterrupted one-pot manner. A further improvement involves the possibility to install an ortho-amino group in situ. A synthetic application of this method is showcased by the concise synthesis of an isocryptolepine alkaloid and its synthetic analogs with potent anticancer activitiesru
dc.relation.ispartofseriesRSC Advances-
dc.subjectAnticancer activityru
dc.subjectChange operationsru
dc.subjectConcise synthesisru
dc.subjectPolyphosphoric acidsru
dc.subjectSecond generationru
dc.subjectSynthetic analogsru
dc.subjectSynthetic applicationru
dc.subjectThree componentru
dc.titleA nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activitiesru
vkr.amountPages 36980-36986ru
vkr.instИнститут математики и естественных наук-
vkr.instИнститут нефти и газа-
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