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Title: Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells
Authors: Aksenov, A. V.
Аксенов, А. В.
Smirnov, A. N.
Смирнов, А. Н.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Keywords: 2 aryl 2 (3 indolyl)acetohydroxamate derivative;Acetohydroxamic acid;Antineoplastic agent;Unclassified drug;Antineoplastic agent;Hydroxamic acid;Indole derivative
Issue Date: 2015
Publisher: American Chemical Society
Citation: Aksenov, A.V., Smirnov, A.N., Magedov, I.V., Reisenauer, M.R., Aksenov, N.A., Aksenova, I.V., Pendleton, A.L., Nguyen, G., Johnston, R.K., Rubin, M., De Carvalho, A., Kiss, R., Mathieu, V., Lefranc, F., Correa, J., Cavazos, D.A., Brenner, A.J., Bryan, B.A., Rogelj, S., Kornienko, A., Frolova, L.V. Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells // Journal of Medicinal Chemistry. - 2015. - Volume 58. - Issue 5. - Pages 2206-2220
Series/Report no.: Journal of Medicinal Chemistry
Abstract: Many types of tumor, including glioma, melanoma, non-small cell lung, esophageal, and head and neck cancer, among others, are intrinsically resistant to apoptosis induction and poorly responsive to current therapies with proapoptotic agents. In addition, tumors often develop multidrug resistance based on the cellular efflux of chemotherapeutic agents. Thus, novel anticancer agents capable of overcoming these intrinsic or developed tumor resistance mechanisms are urgently needed. We describe a series of 2-aryl-2-(3-indolyl)acetohydroxamic acids that are active against apoptosis-and multidrug-resistant cancer cells as well as glioblastoma neurosphere stemlike cell cultures derived from patients. Thus, the described compounds serve as a novel chemical scaffold for the development of potentially highly effective clinical cancer drugs
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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