5% suspension of albendazole echinacea magenta (Echinacea Purpurea) toxicometric evaluation

Abstract

The acute toxicity of 5% suspension of albendazole Echinacea Magenta (Echinaceapurpurea) was studied when administered orally to outbred white mice. To determine the characteristics of the suspension acute toxicity, it was administered to animals once with varying doses. The general condition and behavior of animals were observed during 14 days. The intoxication symptoms' manifestation and possible death were noticed. The animals' death was observed within five days after the drug administration. The drug's acute toxicity characteristics were as follows: MPD -740 mg/kg of body weight, and LD50 - 2960 mg/kg of body weight, LD16 -1450,4 mg/kg, LD84- 6050 mg/kg of body weight. In accordance with Russian State Standard 1.1.007-76, the drug belonged to the class 3 of danger (moderately toxic substance)