Influence of the tissue preparation "NICA-EM" on morphofunctional condition of a liver of rats at norm and at experimental non-alcoholic steatohepatitis

Abstract

The conducted research is devoted to influence of a tissue preparation "NICA-EM" on a morphofunctional condition of a liver of mammals at norm and at an experimental steatohepatitis. Results of research testify that application of a preparation at norm causes to intensification of a number of synthetic processes in a liver, thus, without alteration of morphological integrity of organ. At an experimental non-alcoholic steatohepatitis the preparation provides an expressed hepatoprotective and a metabolism-stabilizing effect. Application of a preparation conducts to preservation of morphological integrity of a liver, normalizes levels of mitotic, necrotic and binuclear cells indexes, increases intensity of apoptosis, also normalizes the level of the content of the main metabolites, characterizing a functional condition of a liver, in blood serum. Thus, it is possible to draw a conclusion on effective influence of a preparation "NICA-EM" on metabolic processes in an organism of a mammal and on its ability to correction of changes in a liver at a serious pathological state - non-alcoholic steatohepatitis