Anti-inflammatory effect of NICA-EM in rodent models of acute inflammation

Abstract

The conducted research is devoted to studying of influence of the tissue preparation "NICA-EM" on an organism of mammals in rodent models of acute inflammation. It is established that at application of the studied preparation on model of acute inflammation the dynamics of inflammatory reaction, characterized by change of affected hind paw volume of an animal, was less expressed in rats of the experimental group. Action of a preparation leads to decrease in rates of ESR and CRP. Hematologic and biochemical parameters also speak well for anti-inflammatory action of "NICA-EM". Results of histological and morphometric research of a spleen and a thymus testify to proliferation and migration of immunocytes, to activization of immune reactions. In a thymus of rats of experimental group in comparison with control the increase in the dimensions of thymic lobules, and also the increase in quantity of Hassal's bodies testifying to intensification of synthesis of the thymic hormones participating in process of an immunopoesis are revealed. As a result of application of a preparation there are an increase of ability of an organism to resist to alteration and also essential decrease in a level of development of inflammatory reaction of an organism. The conducted research testifies to the expressed immunomodulatory action of a preparation "NICA-EM" at an experimental model of inflammation