Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKornienko, A. V.-
dc.contributor.authorКорниенко, А. В.-
dc.identifier.citationMasi, M., Dasari, R., Evidente, A., Mathieu, V., Kornienko, A. Chemistry and biology of ophiobolin A and its congeners // Bioorganic and Medicinal Chemistry Letters. - 2019ru
dc.description.abstractOphiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agentsru
dc.publisherElsevier Ltdru
dc.relation.ispartofseriesBioorganic and Medicinal Chemistry Letters-
dc.subjectAnticancer activityru
dc.subjectApoptosis resistanceru
dc.subjectOphiobolin Aru
dc.titleChemistry and biology of ophiobolin A and its congenersru
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

Files in This Item:
File Description SizeFormat 
scopusresults 843 .pdf63.42 kBAdobe PDFThumbnail
WoS 543 .pdf909.81 kBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.