Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/4471
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKornienko, A. V.-
dc.contributor.authorКорниенко, А. В.-
dc.date.accessioned2019-02-25T12:29:22Z-
dc.date.available2019-02-25T12:29:22Z-
dc.date.issued2019-
dc.identifier.citationMasi, M., Dasari, R., Evidente, A., Mathieu, V., Kornienko, A. Chemistry and biology of ophiobolin A and its congeners // Bioorganic and Medicinal Chemistry Letters. - 2019ru
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85061341873&origin=resultslist&sort=plf-f&src=s&st1=Chemistry+and+biology+of+ophiobolin+A+and+its+congeners&st2=&sid=db77b7f7f1a51320d2d80165480375cc&sot=b&sdt=b&sl=70&s=TITLE-ABS-KEY%28Chemistry+and+biology+of+ophiobolin+A+and+its+congeners%29&relpos=0&citeCnt=0&searchTerm=#-
dc.identifier.urihttp://hdl.handle.net/20.500.12258/4471-
dc.description.abstractOphiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agentsru
dc.language.isoenru
dc.publisherElsevier Ltdru
dc.relation.ispartofseriesBioorganic and Medicinal Chemistry Letters-
dc.subjectAnticancer activityru
dc.subjectApoptosis resistanceru
dc.subjectGlioblastomaru
dc.subjectOphiobolin Aru
dc.subjectSesterterpenesru
dc.titleChemistry and biology of ophiobolin A and its congenersru
dc.typeСтатьяru
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

Files in This Item:
File Description SizeFormat 
scopusresults 843 .pdf63.42 kBAdobe PDFThumbnail
View/Open
WoS 543 .pdf909.81 kBAdobe PDFThumbnail
View/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.