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DC Field | Value | Language |
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dc.contributor.author | Kornienko, A. V. | - |
dc.contributor.author | Корниенко, А. В. | - |
dc.date.accessioned | 2019-02-25T12:29:22Z | - |
dc.date.available | 2019-02-25T12:29:22Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Masi, M., Dasari, R., Evidente, A., Mathieu, V., Kornienko, A. Chemistry and biology of ophiobolin A and its congeners // Bioorganic and Medicinal Chemistry Letters. - 2019 | ru |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85061341873&origin=resultslist&sort=plf-f&src=s&st1=Chemistry+and+biology+of+ophiobolin+A+and+its+congeners&st2=&sid=db77b7f7f1a51320d2d80165480375cc&sot=b&sdt=b&sl=70&s=TITLE-ABS-KEY%28Chemistry+and+biology+of+ophiobolin+A+and+its+congeners%29&relpos=0&citeCnt=0&searchTerm=# | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12258/4471 | - |
dc.description.abstract | Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agents | ru |
dc.language.iso | en | ru |
dc.publisher | Elsevier Ltd | ru |
dc.relation.ispartofseries | Bioorganic and Medicinal Chemistry Letters | - |
dc.subject | Anticancer activity | ru |
dc.subject | Apoptosis resistance | ru |
dc.subject | Glioblastoma | ru |
dc.subject | Ophiobolin A | ru |
dc.subject | Sesterterpenes | ru |
dc.title | Chemistry and biology of ophiobolin A and its congeners | ru |
dc.type | Статья | ru |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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scopusresults 843 .pdf Restricted Access | 63.42 kB | Adobe PDF | View/Open | |
WoS 543 .pdf Restricted Access | 909.81 kB | Adobe PDF | View/Open |
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