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Title: New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles
Authors: Dotsenko, V. V.
Доценко, В. В.
Keywords: Heterocyclization;Cyanoselenoacetamide;Aminomethylation;Mannich reaction;Active methylene chalcogen amides;Cyanothioacetamide;Selenoamides
Issue Date: 2019
Publisher: SPRINGER
Citation: Dotsenko, VV; Frolov, KA; Chigorina, EA; Khrustaleva, AN; Bibik, EY; Krivokolysko, SG. New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles // RUSSIAN CHEMICAL BULLETIN. - 2019. - Том: 68. - Выпуск: 4. - Стр.: 691-707
Series/Report no.: Russian Chemical Bulletin
Abstract: The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[,7)]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2-a][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N-, S,N-, and Se,N-containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic activities
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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