Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/5582
Title: Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles
Authors: Aksenov, A. V.
Аксенов, А. В.
Aksenov, D. A.
Аксенов, Д. А.
Arutiunov, N. A.
Арутюнов, Н. А.
Aksenov, N. A.
Аксенов, Н. А.
Aleksandrova, E. V.
Александрова, Е. В.
Rubin, M. A.
Рубин, М. А.
Keywords: Anticancer activity;Indoles;Nitroalkenes;Spirocyclization
Issue Date: 2019
Publisher: American Chemical Society
Citation: Aksenov, A.V., Aksenov, D.A., Arutiunov, N.A., Aksenov, N.A., Aleksandrova, E.V., Zhao, Z., Du, L., Kornienko, A., Rubin, M. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. - 2019. - Volume 84. - Issue 11. - Pages 7123-7137
Series/Report no.: Journal of Organic Chemistry
Abstract: An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells
URI: https://www.scopus.com/record/display.uri?eid=2-s2.0-85067007191&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles&st2=&sid=0a6da1faec8406656ad1e7a9ab6c75b0&sot=b&sdt=b&sl=147&s=TITLE-ABS-KEY%28Synthesis+of+Spiro%5bindole-3%2c5%E2%80%B2-isoxazoles%5d+with+Anticancer+Activity+via+a+Formal+%5b4+%2b+1%5d-Spirocyclization+of+Nitroalkenes+to+Indoles%29&relpos=0&citeCnt=0&searchTerm=
http://hdl.handle.net/20.500.12258/5582
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