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Title: Synthesis of spiro[indole-3,5′-isoxazoles] with anticancer activity via a formal [4 + 1]-spirocyclization of nitroalkenes to indoles
Authors: Aksenov, A. V.
Аксенов, А. В.
Aksenov, D. A.
Аксенов, Д. А.
Arutiunov, N. A.
Арутюнов, Н. А.
Aksenov, N. A.
Аксенов, Н. А.
Aleksandrova, E. V.
Александрова, Е. В.
Rubin, M. A.
Рубин, М. А.
Keywords: Anticancer activity;Indoles;Nitroalkenes;Spirocyclization
Issue Date: 2019
Publisher: American Chemical Society
Citation: Aksenov, A.V., Aksenov, D.A., Arutiunov, N.A., Aksenov, N.A., Aleksandrova, E.V., Zhao, Z., Du, L., Kornienko, A., Rubin, M. Synthesis of Spiro[indole-3,5′-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles // Journal of Organic Chemistry. - 2019. - Volume 84. - Issue 11. - Pages 7123-7137
Series/Report no.: Journal of Organic Chemistry
Abstract: An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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