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https://dspace.ncfu.ru/handle/20.500.12258/609
Title: | Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds |
Authors: | Dotsenko, V. V. Доценко, В. В. |
Keywords: | Antivirals;Flavivirus;Organoselenium compounds;Tick-borne encephalitis virus |
Issue Date: | 2018 |
Publisher: | Wiley-VCH Verlag |
Citation: | Orlov, A.A., Eletskaya, A.A., Frolov, K.A., Golinets, A.D., Palyulin, V.A., Krivokolysko, S.G., Kozlovskaya, L.I., Dotsenko, V.V., Osolodkin, D.I. Probing chemical space of tick-borne encephalitis virus reproduction inhibitors with organoselenium compounds // Archiv der Pharmazie. - 2018. - Volume 351. - Issue 6. - статья №1700353. |
Series/Report no.: | Archiv der Pharmazie |
Abstract: | Tick-borne encephalitis virus (TBEV), a member of the genus Flavivirus, is the leading cause of arboviral neuroinfections in Europe. Only a few classes of the nucleoside and non-nucleoside inhibitors were investigated against TBEV reproduction. Paving the way to previously unexplored areas of anti-TBEV chemical space, we assessed the inhibition of TBEV reproduction in the plaque reduction assay by various compounds derived from cyanothioacetamide and cyanoselenoacetamide. Compounds from seven classes, including 4-(alkylthio)-2-aryl-3-azaspiro[5.5]undec-4-ene-1,1,5-tricarbonitriles, 3-arylamino-2-(selenazol-2-yl)acrylonitriles, ethyl 6-(alkylseleno)-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylates, 6-(alkylseleno)-2-oxo-1,4,5,6-tetrahydropyridine-3-carbonitriles, 2-(alkylseleno)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitriles, 8-selenoxo-3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-ene-1,9-dicarbonitriles, and selenolo[2,3-b]quinolines, inhibited TBEV reproduction with EC50 values in the micromolar range while showing moderate cytotoxicity and no inhibition of enterovirus reproduction. Thus, new scaffolds with promising anti-TBEV activity were found |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85046075473&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=nort*+caucas*+fed*+univ*&sid=762e6d30544023d6a322a94577ba172b&sot=afnl&sdt=afsp&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&relpos=3&citeCnt=0&searchTerm= https://dspace.ncfu.ru:443/handle/20.500.12258/609 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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scopusresults (89).pdf Restricted Access | 62.83 kB | Adobe PDF | View/Open | |
WoS 64 .pdf Restricted Access | 82.52 kB | Adobe PDF | View/Open |
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