Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/7502
Title: Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents
Authors: Aksenov, N. A.
Аксенов, Н. А.
Skomorokhov, A. A.
Скоморохов, А. А.
Aksenov, A. V.
Аксенов, А. В.
Rubin, M. A.
Рубин, М. А.
Keywords: Indole;Isoxazole;Michael addition;Microwave-assisted synthesis;Nitroalkenes;Pyrazole
Issue Date: 2019
Publisher: Springer New York LLC
Citation: Aksenov, N.A., Skomorokhov, A.A., Aksenov, A.V., Voskressensky, L.G., Rubin, M.A. Michael addition to 3-(2-nitrovinyl)indoles – route toward aliphatic nitro compounds with heterocyclic substituents // Chemistry of Heterocyclic Compounds. - 2019. - Volume 55. - Issue 6. - Pages 541-546
Series/Report no.: Chemistry of Heterocyclic Compounds
Abstract: Synthetic approach toward indole derivatives bearing 2-nitroethyl group and polar azole moiety has been developed. This method involves conjugate addition of 1,3-dicarbonyl compounds to 3-(2-nitrovinyl)-1H-indoles followed by cyclocondensation with hydrazine or hydroxylamine to furnish pyrazole or isoxazole ring. Application of microwave activation allows to obtain the target indole derivatives in short time and avoid protection of indole nitrogen atom
URI: https://www.scopus.com/record/display.uri?eid=2-s2.0-85070100471&origin=resultslist&sort=plf-f&src=s&st1=Michael+addition+to+3-2-nitrovinyl+indoles+--+route+toward+aliphatic+nitro+compounds+with+heterocyclic+substituents&st2=&sid=1c5a6fe41babdcf93eed0c3d463275ee&sot=b&sdt=b&sl=130&s=TITLE-ABS-KEY%28Michael+addition+to+3-2-nitrovinyl+indoles+--+route+toward+aliphatic+nitro+compounds+with+heterocyclic+substituents%29&relpos=0&citeCnt=0&searchTerm=
http://hdl.handle.net/20.500.12258/7502
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