The effect of the developed complex symbiotic composition on the immune and cytokine profile in young cattle in neonatal ontogenesis

Abstract

The humoral link of immunity plays an important role in protecting the body of newborn young animals from diseases of bacterial etiology. Diseases of the gastrointestinal tract in young cattle constitute a significant part. In recent years, more and more attention has been paid to research on probiotherapeutic agents and their effect on animal immunity. In this regard, it is extremely important to develop drugs based on target components, namely certified strains B-2585 Lactobacillus acidophilus 13 and B-2579 Enterococcus faecium K-50 with the inclusion of auxiliary components - inulin and FOS. It has been experimentally proven that the complex synbiotic composition has an effect on increasing the bactericidal and lysozyme activity of blood serum, the absorption and metabolic activity of neutrophils, reducing the content of pro-inflammatory cytokines and their optimal ratio with anti-inflammatory mediators. In addition, probiotic microorganisms included in the product increase the colonization potential of the microflora of the gastrointestinal tract, act as primary antigens for native leukocytes, stimulating the development of an immune response in contact with foreign antigens. These data can be used for further development of drugs based on probiotic microorganisms, in order to increase the nonspecific immunity of the animal.