Data analysis of autoimmune bioindicators in the context of predicting cardiomyocyte damage

Abstract

Department of Physiology and Pathology, Faculty of Medicine and Biology, North Caucasus Federal University, Stavropol, Russian Federation; Department of Therapy, Institute of Clinical Medicine, First Moscow State Medical University named after I.M. Sechenov, Moscow, Russian Federation; Department of Therapy, First Medical Faculty, Medical Institute named after S. I. Georgievsky, Crimea, Simferopol, Russian Federation; Department of Pediatrics, Second Medical Faculty, Medical Institute named after S. I. Georgievsky, Crimea, Simferopol, Russian Federation КРАТКОЕ ОПИСАНИЕ: This study was aimed at assessing the diagnostic significance of Anti-ACTC1, Anti-MYH7B, and Anti-cTnI autoantibodies at the molecular level, as well as their relationship with the results of electrocardiography in predicting damage to the heart muscle in athletes under conditions of physical stress. A medical examination was conducted on 35 men aged 8 to 25 years divided into 2 groups: proffessional basketball players and participants with the usual amount of total motor activity. The study included consultation with medical specialists, physical development research; psychological questionnaires; laboratory screening; and instrumental diagnostics. The values of blood parameters in athletes exceed the reference intervals: the content of erythrocytes by 15.8%, hemoglobin by 11.25%, and hematocrit by 9.1%. The concentration of testosterone in athletes is within the normal range, but during training, it can decrease by 35.5%, indicating anabolism and muscle growth, or overstrain or negative factors. It was found intense stress and emotional stress can cause myocardial stress, microtrauma, and inflammation in the heart muscles, stimulating the immune response and expression of serum antibodies anti-ACTC1, anti-MYH7B, anti-cTnI, as a result of pathophysiological remodeling of the myocardium.