Pseudo Four-Component Cyclocondensation of N-Alkylpiperidin-4-ones, Malononitrile, and Acetone

Abstract

New 8-amino-10-methyl-3-azaspiro[5.5]undeca-8,10-dien-7,7,9-tricarbonitriles were synthesized in 72 and 67% yields by condensation of N-benzyl- or N-ethyl-4-piperidone with malononitrile and acetone in ethanol in the presence of morpholine. The molecular and crystal structures of 8-amino-3-benzyl-10-methyl-3-azaspiro[5.5]undeca-8,10-dien-7,7,9-tricarbonitrile were studied by single crystal X-ray diffraction analysis.