SYNTHESIS OF NANOSIZED ZINC PHOSPHATE STABILIZED WITH BIOLOGICALLY ACTIVE SUBSTANCES

Abstract

The article presents the results of a study of the interaction of zinc phosphate with biologically active substances using the method of quantum chemical modeling, which obtained models of molecules of biologically active substances (essential amino acids), as well as molecular systems Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>–an essential amino acid, in which the interaction of zinc phosphate with an amino acid occurred through an oxygen atom attached to the phosphorus atom in zinc phosphate, and the ionized amino group of the amino acid. As a result of quantum chemical modeling, it is established that the molecular system Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>, an essential amino acid, is energetically advantageous and chemically stable. The optimal configuration with the largest total energy difference (73.646 kcal/mol) and chemical rigidity (0.144 eV) is the Zn<inf>3</inf>(PO<inf>4</inf>)<inf>2</inf>–lysine molecular system, in which the interaction occurs through the ionized H-amino group of lysine. The results of the analysis of the microstructure of zinc phosphate nanoparticles stabilized with L-lysine show that the surface of the samples consists of large aggregates with diameters of 6–17 Pn, which are small spherical particles with dimensions of 100–150 nm. The results of the analysis of the elemental composition allowed us to establish the presence of elements such as zinc and phosphorus in the structure. The phase composition of the samples is studied, as a result, it is determined that the sample of zinc phosphate nanoparticles stabilized with L-lysine has orthorhombic syngony with the space group P nma. The samples were examined by IR spectroscopy, which revealed that the amino acid interaction occurs when phosphate binds through amino groups in the amino acid molecule.