α-Alkyl-α-nitro ketones as 1,2- and 1,1-biselectrophiles. Synthesis of benzoxazoles, benzimidazoles, and quinoxalines

Abstract

The reactivity of α-alkyl-α-nitroacetophenones with 1,2-phenylenediamines and o-aminophenols in acidic medium was examined. The reaction pathway depends on the catalyst used and provides access to the corresponding benzoxazoles, benzimidazoles, and quinoxalines via the aza-Nef-type reaction.