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Title: Strategic approaches to the synthesis of pyrrolizidine and indolizidine alkaloids
Authors: Leontiev, A. V.
Леонтьев, А. В.
Momotova, D. S.
Момотова, Д. С.
Keywords: Indolizidine alkaloids;Organic synthesis strategies;Pyrrolizidine alkaloids;Retrosynthetic analysis
Issue Date: 2020
Publisher: Elsevier Ltd
Citation: Ratmanova, N.K., Andreev, I.A., Leontiev, A.V., Momotova, D., Novoselov, A.M., Ivanova, O.A., Trushkov, I.V. Strategic approaches to the synthesis of pyrrolizidine and indolizidine alkaloids // Tetrahedron. - 2020. - Номер статьи 131031
Series/Report no.: Tetrahedron
Abstract: The principal methods for the synthesis of pyrrolizidine and indolizidine alkaloids and their unnatural analogs are described. Six main “strategic” approaches in regard to a key step forming azabicyclic skeleton are identified. Namely, these are: 1) hydrogenation of the corresponding heteroaromatic compounds; 2) various condensations of carbonyl compounds and their surrogates; 3) cycloaddition reactions; 4) sigmatropic shifts and other rearrangements; 5) transition metal-mediated cyclizations (including the ring-closing alkene metathesis); and 6) radical processes. Such important issues, as retrosynthetic analysis, chiral pool synthesis, and chiral auxiliaries, are also discussed
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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