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Title: Synthesis of 2-(1H-Indol-2-yl)acetamides via bronsted acid-assisted cyclization cascade
Authors: Aksenov, N. A.
Аксенов, Н. А.
Aksenov, D. A.
Аксенов, Д. А.
Skomorokhov, A. A.
Скоморохов, А. А.
Prityko, L. A.
Притыко, Л. А.
Aksenov, A. V.
Аксенов, А. В.
Griaznov, G. D.
Грязнов, Г. Д.
Rubin, M. A.
Рубин, М. А.
Keywords: 2'-aminochalcones;Efficient;Michael addition;Histone;Discovery;Indoles;Reduction;Inhibitory-activity;Nitrostyrenes;Route
Issue Date: 2020
Citation: Aksenov, NA; Aksenov, DA; Skomorokhov, AA; Prityko, LA; Aksenov, AV; Griaznov, GD; Rubin, M. Synthesis of 2-(1H-Indol-2-yl)acetamides via bronsted acid-assisted cyclization cascade // JOURNAL OF ORGANIC CHEMISTRY. - 2020. - Том: 85. - Выпуск: 19. - Стр.: 12128-12146
Series/Report no.: Journal of Organic Chemistry
Abstract: An efficient and straightforward Bronsted-acid mediated cascade process was developed, involving cyclization of readily available beta-ketonitriles into 2-aminofurans, and their subsequent recyclization into 2-(1H-indol-2-yl)acetamides is developed. This synthetic route opens a new avenue for an expeditious assembly of
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