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https://dspace.ncfu.ru/handle/20.500.12258/15166
Title: | Phytosterols: from preclinical evidence to potential clinical applications |
Authors: | Orobinskaya, V. N. Оробинская, В. Н. |
Keywords: | Phytosterols;Coronary heart disease;Beta-sitosterol;Campesterol;Low-density lipoprotein cholesterol |
Issue Date: | 2021 |
Publisher: | FRONTIERS MEDIA SA |
Citation: | Salehi, B; Quispe, C; Sharifi-Rad, J; Cruz-Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, T; Capasso, R; Kukula-Koch, W; Wawruszak, A; Koch, W. Phytosterols: from preclinical evidence to potential clinical applications // FRONTIERS IN PHARMACOLOGY. - 2021. - Том: 11. - Номер статьи: 599959 |
Series/Report no.: | FRONTIERS IN PHARMACOLOGY |
Abstract: | Phytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by several factors (type, source, processing, preparation, delivery method, food matrix, dose, time of administration into the body, and genetic factors), and the existence of a close relationship between their chemical structures (e.g., saturation degree and side-chain length) and low absorption rates has been stated. In this sense, the present review intends to provide in-depth data on PS therapeutic potential for human health, also emphasizing their preclinical effects and bioavailability-related issues |
URI: | http://hdl.handle.net/20.500.12258/15166 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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WoS 1015 .pdf Restricted Access | 1.55 MB | Adobe PDF | View/Open | |
scopusresults 2063 .pdf Restricted Access | 64.81 kB | Adobe PDF | View/Open |
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