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dc.contributor.authorDotsenko, V. V.-
dc.contributor.authorДоценко, В. В.-
dc.contributor.authorAksenov, N. A.-
dc.contributor.authorАксенов, Н. А.-
dc.contributor.authorAksenova, I. V.-
dc.contributor.authorАксенова, И. В.-
dc.identifier.citationDotsenko, V.V., Khrustaleva, A.N., Frolov, K.A., Aksenov, N.A., Aksenova, I.V., Krivokolysko, S.G. 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction // Russian Journal of General Chemistry. - 2021. - Volume 91. - Issue 1. - Pages 44-56ru
dc.description.abstract1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5-a]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried outru
dc.publisherPleiades journalsru
dc.relation.ispartofseriesRussian Journal of General Chemistry-
dc.subjectMannich reactionru
dc.title1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reactionru
vkr.instХимико-фармацевтический факультетru
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