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https://dspace.ncfu.ru/handle/20.500.12258/15477
Title: | 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction |
Authors: | Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
Keywords: | 1,2,4-triazolo[1,5-a]pyridines;2-cyanoacethydrazide;3,7-diazabicyclo[3.3.1]nonanes;aminomethylation;Mannich reaction |
Issue Date: | 2021 |
Publisher: | Pleiades journals |
Citation: | Dotsenko, V.V., Khrustaleva, A.N., Frolov, K.A., Aksenov, N.A., Aksenova, I.V., Krivokolysko, S.G. 1,6-Diamino-2-oxopyridine-3,5-dicarbonitrile Derivatives in the Mannich Reaction // Russian Journal of General Chemistry. - 2021. - Volume 91. - Issue 1. - Pages 44-56 |
Series/Report no.: | Russian Journal of General Chemistry |
Abstract: | 1,6-Diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles under the action of primary aliphatic amines and an excess of 37% formalin in ethanol were converted into 2,3,8,9-tetrahydro-6,10-methano[1,2,4]triazolo[1,5-a][1,5]diazocine-6,10(7H)-dicarbonitrile derivatives. At the same time, the Mannich reaction in the case of 1,6-diamino-4-aryl-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles proceeds ambiguously, and, depending on the conditions, gives either N-ethoxymethylation products or 1,2,4-triazolo[1,5-a]pyridine derivatives. In silico predictive analysis of the biological activity of new compounds was carried out |
URI: | http://hdl.handle.net/20.500.12258/15477 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
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scopusresults 1605 .pdf Restricted Access | 856.33 kB | Adobe PDF | View/Open | |
WoS 1025 .pdf Restricted Access | 138.74 kB | Adobe PDF | View/Open |
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