Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/15557
Title: Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
Authors: Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Shcherbakov, S. V.
Щербаков, С. В.
Ovcharov, S. N.
Овчаров, С. Н.
Keywords: 2-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates;Analgesics;Cyanothioacetamide;Mannich reaction;Pyrido[2,1-b][1,3,5]thiadiazines
Issue Date: 2021
Publisher: Pleiades journals
Citation: Bibik, I.V., Bibik, E.Y., Dotsenko, V.V., Frolov, K.A., Krivokolysko, S.G., Aksenov, N.A., Aksenova, I.V., Shcherbakov, S.V., Ovcharov, S.N. Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives // Russian Journal of General Chemistry. - 2021. - Volume 91. - Issue 2. - Pages 154-166
Series/Report no.: Russian Journal of General Chemistry
Abstract: The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics
URI: http://hdl.handle.net/20.500.12258/15557
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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