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Title: Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives
Authors: Dotsenko, V. V.
Доценко, В. В.
Aksenov, N. A.
Аксенов, Н. А.
Aksenova, I. V.
Аксенова, И. В.
Shcherbakov, S. V.
Щербаков, С. В.
Ovcharov, S. N.
Овчаров, С. Н.
Keywords: 2-oxo-3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates;Analgesics;Cyanothioacetamide;Mannich reaction;Pyrido[2,1-b][1,3,5]thiadiazines
Issue Date: 2021
Publisher: Pleiades journals
Citation: Bibik, I.V., Bibik, E.Y., Dotsenko, V.V., Frolov, K.A., Krivokolysko, S.G., Aksenov, N.A., Aksenova, I.V., Shcherbakov, S.V., Ovcharov, S.N. Synthesis and analgesic activity of new heterocyclic cyanothioacetamide derivatives // Russian Journal of General Chemistry. - 2021. - Volume 91. - Issue 2. - Pages 154-166
Series/Report no.: Russian Journal of General Chemistry
Abstract: The reaction of cyanothioacetamide with aromatic aldehydes and 1,3-dicarbonyl compounds followed by aminomethylation or S-alkylation gave a series of heterocyclic derivatives with a 1,2,3,4-tetrahydropyridine or 1,4,5,6,7,8-hexahydroquinoline fragment. The resulting compounds were tested for analgesic activity in vivo. Some of the prepared compounds showed an antinociceptive effect superior to that of ketorolac in dynamics
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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