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https://dspace.ncfu.ru/handle/20.500.12258/18098
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DC Field | Value | Language |
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dc.contributor.author | Aksenov, A. V. | - |
dc.contributor.author | Аксенов, А. В. | - |
dc.contributor.author | Arutiunov, N. A. | - |
dc.contributor.author | Арутюнов, Н. А. | - |
dc.contributor.author | Kirilov, N. K. | - |
dc.contributor.author | Кирилов, Н. К. | - |
dc.contributor.author | Aksenov, D. A. | - |
dc.contributor.author | Аксенов, Д. А. | - |
dc.contributor.author | Grishin, I. Y. | - |
dc.contributor.author | Гришин, И. Ю. | - |
dc.contributor.author | Aksenov, N. A. | - |
dc.contributor.author | Аксенов, Н. А. | - |
dc.contributor.author | Rubin, M. A. | - |
dc.contributor.author | Рубин, М. А. | - |
dc.date.accessioned | 2021-09-06T13:53:57Z | - |
dc.date.available | 2021-09-06T13:53:57Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Aksenov, A. V.; Arutiunov, N. A.; Kirilov, N. K.; Aksenov, D. A.; Grishin, I. Y.; Aksenov, N. A.; Wang, H.; Du, L.; Betancourt, T.; Pelly, S. C.; Kornienko, A.; Rubin, M. [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor // Organic and Biomolecular Chemistry. - 2021. - Том 19. - Выпуск 33. - Стр.: 7234 - 7245 | ru |
dc.identifier.uri | http://hdl.handle.net/20.500.12258/18098 | - |
dc.description.abstract | Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin polymerization and it is thus proposed that the discovered chemistry can be exploited for the development of novel microtubule-targeting anticancer agents | ru |
dc.language.iso | en | ru |
dc.publisher | Royal Society of Chemistry | ru |
dc.relation.ispartofseries | Organic and Biomolecular Chemistry | - |
dc.subject | Indolizines | ru |
dc.subject | Pyrazolo[1,5-a]pyridines | ru |
dc.subject | Indolizine 9db | ru |
dc.subject | Anticancer agents | ru |
dc.title | [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor | ru |
dc.type | Статья | ru |
vkr.inst | Химико-фармацевтический факультет | ru |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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scopusresults 1858 .pdf Restricted Access | 2.96 MB | Adobe PDF | View/Open | |
WoS 1220 .pdf Restricted Access | 192.62 kB | Adobe PDF | View/Open |
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