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Title: | [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor |
Authors: | Aksenov, A. V. Аксенов, А. В. Arutiunov, N. A. Арутюнов, Н. А. Kirilov, N. K. Кирилов, Н. К. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. |
Keywords: | Indolizines;Pyrazolo[1,5-a]pyridines;Indolizine 9db;Anticancer agents |
Issue Date: | 2021 |
Publisher: | Royal Society of Chemistry |
Citation: | Aksenov, A. V.; Arutiunov, N. A.; Kirilov, N. K.; Aksenov, D. A.; Grishin, I. Y.; Aksenov, N. A.; Wang, H.; Du, L.; Betancourt, T.; Pelly, S. C.; Kornienko, A.; Rubin, M. [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor // Organic and Biomolecular Chemistry. - 2021. - Том 19. - Выпуск 33. - Стр.: 7234 - 7245 |
Series/Report no.: | Organic and Biomolecular Chemistry |
Abstract: | Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin polymerization and it is thus proposed that the discovered chemistry can be exploited for the development of novel microtubule-targeting anticancer agents |
URI: | http://hdl.handle.net/20.500.12258/18098 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
File | Description | Size | Format | |
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scopusresults 1858 .pdf Restricted Access | 2.96 MB | Adobe PDF | View/Open | |
WoS 1220 .pdf Restricted Access | 192.62 kB | Adobe PDF | View/Open |
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