Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives

Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/18827

Title:	Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives
Authors:	Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Aksenov, N. A. Аксенов, Н. А. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Rubin, M. A. Рубин, М. А.
Keywords:	1,3,4-oxadiazoles;1,3,4-thiadiazoles;Amino acids;Brønsted acid catalysis;Cascade reaction;Nitroalkanes;Nucleophilic cycloaddition;Semicarbazides
Issue Date:	2022
Publisher:	Springer
Citation:	Aksenov, A. V., Kirilov, N. K., Aksenov, N. A., Arutiunov, N. A., Aksenov, D. A., Rubin, M. A. Electrophilically activated nitroalkanes in the synthesis of substituted 1,3,4-oxadiazoles from amino acid derivatives // Chemistry of Heterocyclic Compounds. - 2022. - DOI10.1007/s10593-022-03053-2
Series/Report no.:	Chemistry of Heterocyclic Compounds
Abstract:	Novel preparative approach for the synthesis of alkylamines with 1,3,4-oxadiazole heterocyclic substituent is described. This method is based on unusual cascade transformation involving formal (4+1) cyclocondensation of hydrazides of amino acids with nitroalkanes electrophilically activated in the presence of polyphosphoric acid.
URI:	http://hdl.handle.net/20.500.12258/18827
Appears in Collections:	Статьи, проиндексированные в SCOPUS, WOS

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