Design, Synthesis, and Screening of Pyridothieno[3,2- b ]indole and Pyridothieno[3,2- c ]cinnoline Derivatives as Potential Biologically Active Molecules

Abstract

New pyridothieno[3,2-b]indole and pyridothieno[3,2-c]cinnoline derivatives are designed and prepared from the corresponding 3- amino-2-arylthieno[2,3-b]pyridines. By a molecular docking method novel potential inhibitors of DNA gyrase B are identified among the thieno[2,3-b]pyridine derivatives. In addition, some of the prepared pyridothienoindoles exhibit in vivo antidote activity against the herbicide 2,4-D.