Репозиторий научных и учебно-методических публикаций
ФГАОУ ВО «Северо-Кавказский федеральный университет»
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https://dspace.ncfu.ru/handle/20.500.12258/21960| Title: | Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities |
| Authors: | Aksenov, A. V. Аксенов, А. В. Kirilov, N. K. Кирилов, Н. К. Arutiunov, N. A. Арутюнов, Н. А. Aksenov, D. A. Аксенов, Д. А. Kuzminov, I. K. Кузьминов, И. К. Aksenov, N. A. Аксенов, Н. А. Rubin, M. A. Рубин, М. А. |
| Keywords: | Polycyclic aromatic hydrocarbons;Sodium Borohydride |
| Issue Date: | 2022 |
| Publisher: | American Chemical Society |
| Citation: | Aksenov, A.V., Kirilov, N.K., Arutiunov, N.A., Aksenov, D.A., Kuzminov, I.K., Aksenov, N.A., Turner, D.N., Rogelj, S., Kornienko, A., Rubin, M. Reductive Cleavage of 4′ H-Spiro[indole-3,5′-isoxazoles] en Route to 2-(1 H-Indol-3-yl)acetamides with Anticancer Activities // Journal of Organic Chemistry. - 2022. - Volume 87. - Issue 21. - Pages 13955-13964. - DOI10.1021/acs.joc.2c01627 |
| Series/Report no.: | Journal of Organic Chemistry |
| Abstract: | Unusual cascade transformation involving ring opening and 1,2-alkyl shift was observed upon the reduction of 4′H-spiro[indole-3,5′-isoxazoles] or 2-(3-oxoindolin-2-yl)acetonitriles with sodium borohydride. This reaction allowed for expeditious and highly efficient preparation of 2-(1H-Indol-3-yl)acetamides with antiproliferative properties. |
| URI: | http://hdl.handle.net/20.500.12258/21960 |
| Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| scopusresults 2399 .pdf Restricted Access | 64.65 kB | Adobe PDF | View/Open | |
| WoS 1491 .pdf Restricted Access | 118.98 kB | Adobe PDF | View/Open |
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