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Title: | Synthesis and Structure of 4-Aryl-3,6-dioxo-2,3,4,5,6,7-hexahydroisothiazolo[5,4-b]pyridine-5-carbonitriles |
Authors: | Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
Keywords: | Active methylene thioamides;Monothiomalondiamide;Oxidation;DMSO;Isothiazolo[5,4-b]pyridines;Calculated biological activity |
Issue Date: | 2022 |
Citation: | Dotsenko, V.V., Jassim, N.T., Temerdashev, A.Z., Aksenov, N.A., Aksenova, I.V. Synthesis and Structure of 4-Aryl-3,6-dioxo-2,3,4,5,6,7-hexahydroisothiazolo[5,4-b]pyridine-5-carbonitriles // Russian Journal of General Chemistry. - 2022. - 92(12), pp. 2861 - 2869. - DOI: 10.1134/S1070363222120386 |
Series/Report no.: | Russian Journal of General Chemistry |
Abstract: | Oxidation of triethylammonium 6-amino-4-aryl-3-carbamoyl-5-cyano-1,4-dihydropyridine-2-thiolates with DMSO–HCl system leads to the formation of novel 4-aryl-3,6-dioxo-2,3,4,5,6,7-hexahydroisothiazolo[5,4-b]-pyridine-5-carbonitiriles. Structure of the obtained compounds was studied using two-dimensional NMR spectros-copy and HRMS methods. An in silico predictive analysis was carried out to identify bioavailability parameters and possible protein targets for the obtained compounds. |
URI: | http://hdl.handle.net/20.500.12258/22947 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
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scopusresults 2500 .pdf Restricted Access | 733.54 kB | Adobe PDF | View/Open | |
WoS 1543 .pdf Restricted Access | 113.95 kB | Adobe PDF | View/Open |
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