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Title: One-pot, three-component assembly of indoloquinolines: total synthesis of isocryptolepine
Authors: Aksenov, A. V.
Аксенов, А. В.
Aksenov, D. A.
Аксенов, Д. А.
Orazova, N. A.
Оразова, Н. А.
Aksenov, N. A.
Аксенов, Н. А.
Griaznov, G. D.
Грязнов, Г. Д.
Rubin, M. A.
Рубин, М. А.
Keywords: Anti-proliferative activities;Chemistry;Arylhydrazines;Synthetic analogues;Synthetic application;Three component;Total synthesis
Issue Date: 2017
Publisher: American Chemical Society
Citation: Aksenov, A.V., Aksenov, D.A., Orazova, N.A., Aksenov, N.A., Griaznov, G.D., De Carvalho, A., Kiss, R., Mathieu, V., Kornienko, A., Rubin, M. One-Pot, Three-Component Assembly of Indoloquinolines: Total Synthesis of Isocryptolepine // Journal of Organic Chemistry. - 2017. - Volume 82. - Issue 6. - Pages 3011-3018
Series/Report no.: Journal of Organic Chemistry
Abstract: Indolo[3,2-c]quinolones have been efficiently synthesized via an acid-mediated, one-pot, three-component condensation of arylhydrazines, o-aminoacetophenones, and triazines or nitriles. The synthetic application of this method is showcased by the concise synthesis of isocryptolepine alkaloid and a series of its synthetic analogues with demonstrated cancer cell antiproliferative activities
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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